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Burden and trend of colorectal cancer in 54 countries of Africa 2010–2019: a systematic examination for Global Burden of Disease
Abstract Background: Colorectal cancer plays signifcant role in morbidity, mortality and economic cost in Africa. Objective: To investigate the burden and trends of incidence, mortality, and disability-adjusted life-years (DALYs) of colorectal cancer in Africa from 2010 to 2019. Methods: This study was conducted according to [...]
Age-standardised incidence rate and epidemiology of colorectal cancer in Africa: a systematic review and metaanalysis
ABSTRACT Objectives Colorectal cancer (CRC) is the second-leading cause of cancer deaths globally, with low-income and middle-income countries (LMICs) disproportionately affected. Estimates of CRC rates in LMIC are scarce. We aimed to (1) estimate sex-specific incidence of CRC, (2) estimate temporal trend and (3) determine [...]
Inflammatory Bowel Disease On-Line Web-Based Guide to Health Professionals and Patients in Developing and African Nations
1.1. Introduction: Inflammatory Bowel Disease (IBD) is recklessly evolving worldwide as incautious disaster, especially in developing nations as a regional duplicitous emergence disease. It has come to light that adaptive Western culture, rapid urbanization lifestyle in the developing nations have been seen to be associated [...]
The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview
The gastrointestinal system where inflammatory bowel disease occurs is central to the immune system where the innate and the adaptive/acquired immune systems are balanced in interactions with gut microbes under homeostasis conditions. This article overviews the high-throughput research screening on multifactorial interplay between genetic risk [...]
Inflammatory bowel disease in Africa: what is the current state of knowledge?
Inflammatory bowel disease (IBD) is increasingly recognized as a global disease in the twenty-first century; however, little is known about its epidemiology in Africa. We conducted a literature review in order to assess what is currently known on this subject, the results of which are [...]
Inflammatory bowel disease in Accra: what new trends
Background: Inflammatory bowel disease (IBD) has been more common in Western Europe and North America. Initially IBD had been thought to be low in incidence among Sub-Saharan Africans. However, it is now being increasingly recognised in patients of African descent. Objective: A comparative assessment of [...]
Ulcerative colitis: a case in Togo
Ulcerative colitis seems to be rare in sub-Saharan Africa. Because its clinical and radiological signs are non-specific, anatomopathologic studies are necessary for definitive diagnosis after exclusion of parasitic, bacterial, and viral causes. The purpose of this report is to describe a fatal case of ulcerative [...]
The epidemiology of inflammatory bowel disease in Cape Town 1980-1984
Patients with inflammatory bowel disease diagnosed in the greater Cape Town area between the years 1980 and 1984 inclusive were studied to establish the incidence and presenting features of these diseases. Case details were obtained from the records of the Groote Schuur Hospital group and [...]
Ulcerative colitis in a developing country of Africa: the Baragwanath experience of the first 46 patients
Ulcerative colitis is reported to be rare in black populations of sub-Saharan Africa. This series of the first 46 patients treated at Baragwanath Hospital, Soweto, indicates that most patients (72%) presented with severe symptoms and extensive colonic involvement. There is a paradox of severe extensive [...]
Dermatologic manifestations in inflammatory bowel disease in Tunisia
Background: Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease (IBD). Aim: To assess the epidemio-clinical profile of skin manifestations in IBD. Methods: A prospective and descriptive study was conducted. We have examined skin, mucosa, hair and nails, of all [...]
Ulcerative colitis in a Nigerian girl: a case report
Background: Ulcerative colitis (UC) is uncommon in the tropics and sub-tropics. We report a case of UC in a 7 year old girl whose parents were both Nigerians. This report is to alert healthcare professionals in sub-Saharan Africa that UC is not a rare health [...]
Analysis of the three common mutations in the CARD15 gene (R702W, G908R and 1007fs) in South African colored patients with inflammatory bowel disease
The caspase recruitment domain-containing protein 15 gene (CARD15) was recently identified as an important susceptibility gene for Crohn's disease (CD). The purpose of this study was to assess the likelihood that the three most common CARD15 mutations, R702W, G908R and 1007fs, contribute to inflammatory bowel [...]
Inflammatory bowel disease in rural sub-Saharan Africa: rarity of diagnosis in patients attending mission hospitals
One hundred and eighteen missionaries working on 75 mission stations or hospitals in 24 sub-Saharan African countries provided information about their medical practice in the preceding year of 1981. Details were collected of the total number of patients seen and admitted during the year, and [...]
Inflammatory Bowel Disease at the Korle Bu Teaching Hospital, Accra
Case files of patients with Inflammatory Bowel Disease (IBD) managed by the author in the Medical Department over the period 1997 – 2004 have been reviewed to identify some features of the disease that may aid improved diagnosis and management. The findings indicate that IBD [...]
Ulcerative colitis in a Nigerian girl: a case report
Background: Ulcerative colitis (UC) is uncommon in the tropics and sub-tropics. We report a case of UC in a 7 year old girl whose parents were both Nigerians. This report is to alert healthcare professionals in sub-Saharan Africa that UC is not a rare health [...]
The rarity of ulcerative colitis in South African blacks
Ulcerative colitis is rare in black populations of sub-Saharan African. Only 18 cases were reported up to 1975. Since then, in four years, an additional 13 patients have been diagnosed at Baragwanath Hospital, Johannesburg. This hospital, with 2,700 beds, serves a population of approximately 1 [...]
Inflammatory bowel disease in Cape Town, 1975-1980. Part I. Ulcerative colitis
Previously documented and new patients with ulcerative colitis seen between 1975 and 1980 in the Gastro-intestinal Clinic of Groote Schuur Hospital were studied to establish the local incidence and clinical features of this disease. There were 220 patients and the mean follow-up was 7,7 +/- [...]
Inflammatory bowel disease in Cape Town, 1975-1980. Part II. Crohn’s disease
Patients with Crohn's disease seen in the Gastro-intestinal Clinic of Groote Schuur Hospital between 1975 and 1980 were studied to establish the incidence and clinical features of this disease. There were 117 patients and the mean (+/- SEM) follow-up was 6,1 +/- 0,5 years. Of [...]
Medium-term follow-up of ulcerative colitis in Cape Town
The 114 patients with ulcerative colitis diagnosed in Greater Cape Town between 1970 and 1979 were followed up 11 years later. Ninety per cent of those contacted were in remission or had mild symptoms only. Eleven patients had died; 3 deaths (in total colitis patients) [...]